Portfolio Companies

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Aptinyx

Aptinyx

Neurology | Clinical | IPO

Clinical company developing platform of neuromodulators for neurology indications.

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Carisma Therapeutics

Carisma Therapeutics

Oncology | Clinical | Active

Preclinical company developing immunotherapy platform for oncology applications.

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Dice Molecules

Dice Molecules

Oncology, Immunology | Preclinical | Active

Preclinical company bringing directed chemical evolution to small molecule drug discovery.

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Dragonfly Therapeutics

Dragonfly Therapeutics

Oncology, Immunology | Clinical | Active

Clinical stage company targeting Natural Killer cells for immuno-oncology applications.

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Entrada Therapeutics

Entrada Therapeutics

Rare Disease | Preclinical | Active

Preclinical company developing novel treatments for rare disease.

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Freenome

Freenome

Oncology | Clinical | Active

Clinical stage company using AI genomics for early cancer detection.

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ImCheck Publishes Seminal Paper in Cell Reports Elucidating How Butyrophilins Activate Vγ9Vδ2 T cell Function Against Tumor Cells

ImCheck Publishes Seminal Paper in Cell Reports Elucidating How Butyrophilins Activate Vγ9Vδ2 T cell Function Against Tumor Cells

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ImCheck Therapeutics today announced the publication of preclinical data elucidating the fundamental role of butyrophilins (BTNs) in the activation of V gamma 9 V delta 2 (γ9δ2) T cells leading to an anti-tumor immune response in the peer-reviewed journal, Cell Reports. The publication, titled “BTN2A1, An Immune-checkpoint Targeting Vγ9Vδ2 T Cell Cytotoxicity Against Malignant Cells” summarizes the findings of the interaction between specific BTN subtypes that efficiently activate Vγ9Vδ2 T cells, an important subset of cytotoxic γδ T cells. In addition, the publication demonstrates that an anti-BTN2A1-specific antibody is able to inhibit the cytotoxic function of the Vγ9Vδ2 T cells. The article was authored by ImCheck scientists in collaboration with the laboratory of Prof. Daniel Olive, Professor of Immunology and Director of the Oncology Research Programs at Aix Marseille University and the company’s scientific founder.https://www.imchecktherapeutics.com/all-press-release/news/imcheck-publishes-seminal-paper-in-cell-reports-elucidating-how-butyrophilins-activate-vg9vd2-t-cell-function-against-tumor-cells/

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ImCheck Therapeutics

ImCheck Therapeutics

Oncology | Clinical | Active

Clinical stage company developing novel immuno-oncology antibodies targeting gamma delta T-cells.

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Interius BioTherapeutics

Interius BioTherapeutics

Oncology | Preclinical | Active

Preclinical stage gene therapy company developing a paradigm-shifting platform for in vivo cell-specific gene delivery.

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Metagenomi

Metagenomi

Rare Disease, Oncology, Immunology | Preclinical | Active

Preclinical stage company discovering breakthrough gene editing systems for curing disease.

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Orbus Therapeutics

Orbus Therapeutics

Oncology | Clinical | Active

Clinical company developing therapeutics for rare brain tumors.

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Orchard Therapeutics

Orchard Therapeutics

Rare Disease, Neurology, Immunology | Commercial | IPO

Commercial company developing gene therapies for rare immunology disorders.

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Palvella Therapeutics

Palvella Therapeutics

Rare Disease, Immunology | Clinical | Active

Clinical stage company developing therapeutics for rare dermatological disorders.

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Pliant Therapeutics

Pliant Therapeutics

Rare Disease | Clinical | IPO

Clinical stage company developing therapeutics targeting key biological pathways in fibrosis.

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Precision Biosciences

Precision Biosciences

Rare Disease, Oncology | Clinical | IPO

Clinical stage company developing gene-editing platform for oncology and rare diseases.

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Pyxis Oncology

Pyxis Oncology

Oncology | Preclinical | Active

Preclinical company developing antibody-based immunotherapies.

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Skyhawk Therapeutics

Skyhawk Therapeutics

Rare Disease, Oncology, Neurology | Preclinical | Active

Preclinical company developing platform to correct RNA expression in neurology, oncology and rare diseases.

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